Trade Name: GIFLOX - XR
Generic Name:
Ciprofloxacin 500 mg
Presentation
Geflox 250 : Each tablet contains Ciprofloxacin HCI USP equivalent to
Ciprofloxacin 250 mg.
Geflox 500 : Each tablet contains Ciprofloxacin HCI USP equivalent to
Ciprofloxacin 500 mg.
Geflox XR : Each XR-tablet contains Ciprofloxacin hydrochloride BP
equivalent to Ciprofloxacin 500 mg.
Indications
| * Respiratory tract infections
|
* Intra-abdominal infections |
| * Ear, nose, and throat
infections |
* Infections of the biliary
tract |
| * Eye infections |
* Gastro intestinal infections |
| * Urinary tract infections |
* Severe systemic infections |
| * Skin and soft tissue
infections |
* Gonorrhoea |
| * Bone and joint infections |
|
Dosage & Administration
Adults :
General dosage recommendations
|
Infections |
Type or severity |
Unit dose |
Frequency |
Usual duration |
|
Urinary tract |
Acute uncomplicated |
100 mg/250 mg |
12 hourly |
3 days |
|
Mild/Moderate |
250 mg |
12 hourly |
7 to 14 days |
|
Severe/Complicated |
500 mg |
12 hourly |
7 to 14 days |
|
Lower respiratory tract |
Mild/Moderate |
500 mg |
12 hourly |
7 to 14 days |
|
Acute sinusitis |
Severe/Complicated |
750 mg |
12 hourly |
7 to 14 days |
|
Mild/Moderate |
500 mg |
12 hourly |
10 days |
|
Skin & skin structure |
Mild/Moderate |
500 mg |
12 hourly |
7 to 14 days |
|
Severe/Complicated |
750 mg |
12 hourly |
7 to 14 days |
|
Bone & joint |
Mild/Moderate |
500 mg |
12 hourly |
>
4 to 6 weeks |
|
Severe/Complicated |
750 mg |
12 hourly |
>
4 to 6 weeks |
|
Intra-abdominal |
Complicated |
500 mg |
12 hourly |
7 to 14 days |
|
Infectious diarrhea |
Mild/Moderate/Severe |
500 mg |
12 hourly |
5 to 7 days |
|
Typhoid fever |
Mild/Moderate |
500 mg |
12 hourly |
10 days |
|
Urethral and cervical
Gonococcal Infections |
Uncomplicated |
250 mg |
Single dose |
Single dose |
Dosage of Geflox-XR
|
Infections |
Type or severity |
Unit dose |
Frequency |
Usual duration |
|
Urinary tract infections
(Acute cystitis) |
Uncomplicated |
500 mg |
Once daily |
3 days |
|
Complicated |
1000 mg |
Daily |
7 to 14 days |
|
pyelonephritis |
Acute uncomplicated |
1000 mg |
Daily |
7 to 14 days |
In
acute uncomplicated pyelonephritis where 1000 mg is the appropriate dose, the
dosage of Ciprofloxacin-XR should be reduced to 500 mg-XR tablet daily in
patients with creatinine clearance below 30 ml/min.
Childeren :
In
complicated urinary tract infection or pyelonephritis (patients from 1 to 70
years of age) where the benefit is considered to outweigh the potential risk,
the usual dose is 10-30 mg/kg (maximum 750 mg per dose; not to be exceeded even
in patients weighing >51 kg) in 2 divided doses for 10-12 days.
Side effects:
Ciprofloxacin is generally well tolerated. The most frequently reported adverse
reactions are nausea, diarrhea, vomiting, abdominal pain, discomfort, headache,
restlessness and rash.
Contraindications :
Ciprofloxacin is contraindicated in patients who have shown hypersensitivity to
ciprofloxacin. Except in cases of exacerbation of cystic fibrosis associated
with P. aeruginosa (in patients aged 5-17 years), ciprofloxacin is
contraindicated in children and growing adolescents unless the benefits of
treatment are considered to outweigh the risks.
Caution
Ciprofloxacin should be used with caution in epileptics and patients with a
history of CNS disorders and only if the benefits of the treatment are
considered to outweigh the risk of possible CNS side effects.
Alteration of the dosage regimen is necessary for patients with impairment of
renal function.
Use in pregnancy and lactation
Not
recommended.
Drug interactions
When Ciprofloxacin tablet is given concomitantly with food, there is a delay in
the absorption of the drug whereas there is no delay observed when ciprofloxacin
suspension is given with food. Concurrent administration of antacids containing
magnesium hydroxide or aluminum hydroxide may reduce the bioavailability of
ciprofloxacin by as much as 90%. Ciprofloxacin may increase the effects of
theophylline and caffeine.
Commercial pack
Geflox 250 : Each box contains 3 blister strips of 10 tablets.
Geflox 500 : Each box contains 3 blister strips of 10 tablets.
Geflox SR : Each box
contains 2 blister strips of 10 tablets.
|
