Trade Name: CADMIN PLUS
Generic Name: Calcium + Vitamin D + Multimineral Tablet

Presentation

Calcium 600 mg, Vitamin D3 200 IU., Copper 1 mg, Magnesium 40 mg, Manganese 1.8 mg, Zinc 7 mg, Boron 0.25 mg.

Indications

• Osteoporosis

• Softening of the bones when there is lack of vitamin D in the body (osteomalacia)

• Vitamin D and calcium deficiency

• Vitamin D and calcium supplementation in pregnancy

Dosage & Administration

Adults and elderly and children above 12 years of age: 2 tablets per day, preferably one tablet each morning and evening.

Children :Not recommended for children under 12 years.

Precautions

Patients with mild to moderate renal failure or mild hypercalciuria should be supervised carefully, Periodic checks of plasma calcium levels and urinary calcium excretion should be mode in patients with mild to moderate renal failure or mild hypercalciuria. Urinary calcium excretion should also be measured. In patients with a history of renal stones urinary calcium excretion should be measured to exclude hypercalciuria.

Side effects

The use of calcium supplements has, rarely, given rise to mild gastro-intestinal disturbances, such as constipation, flatulence, nausea, gastric pain, diarrhoea. Following administration of vitamin D supplements occasional skin rash has been reported. Hypercalciuria, and in rare cases hypercalcaemia been seen with long-term treatment at high dosages.

Contraindications

Absolute contraindications are hypercalcaemia resulting for example from myeloma, bone metastases or other malignant bone disease, sarcoidosis; primary hyperparathyroidism and vitamin D over dosage. Severe renal failure. Hypersensitivity to any of the tablet ingredients. Relative contraindications are osteoporosis due to prolonged immobilization, renal stones, and severe hypercalciuria.

Drug interactions

The risk of hypercalcaemia should be considered in patients taking thiazide diuretics since these drugs can reduce urinary calcium excretion. Certain foods (e.g. those containing oxalic acid, phosphate or phytinic acid) may reduce the absorption of calcium. Concomitant treatment with phenytoin or barbiturates can decrease the effect of vitamin D because of metabolic activation. Concomitant use of glucocorticoids can decrease the effect of vitamin D. Calcium salts may reduce the absorption of thyroxine, bisphosphonates, sodium fluoride, quinolone or iron.

Pregnancy and lactation

During pregnancy and lactation treatment with this combination should always be under the direction of physician.

Pharmaceutical Precautions

Each air tight container contains 30 or 15 tablets.