Trade Name: EXTRANIL TABLET 5 MG
Generic Name: Procyclidine hydrochloride USP

Description:

Extranil (Procyclidine hydrochloride) is a synthetic antimuscarinic antiparkinsonian agent. It has been shown to be useful for the treatment of parkinsonism including post encephalitic, arteriosclerotic and idiopathic types. Extranil successfully relieves the symptoms of extrapyramidal dysfunction (e.g. Dystonia, Akathisia & Dyskinesia) which accompany the therapy of mental disorder with phenothiazine or other drugs.

Presentation :

Each tablet contains Procyclidine hydrochloride USP 5 mg.

Indication:

All forms of Parkinson's disease e.g.

• idiopathic pardinsonism

• post-encephalitic parkinsonism

• arteriosclerotic parkinsonism

Extrapyramidal symptoms e.g.

• pseudo-parkinsonism

• acute dystonic reactions

• akathisia

induced by neuroleptic drugs such as phenothiazine derivatives.

Dosage and Administration:

Parkinsonism: Initially 2.5 mg 3 times daily, increasing by 2.5-5 mg daily at intervals of 2 or 3 days until the optimum clinical response is achieved. The usual maximum dose is 30 mg daily in divided doses and may be increased upto 60 mg daily in divided doses.

Drug induced extrapyramidal symptom: Initially 2.5 mg 3 times daily. The dosage being increased by 2.5 mg per day as needed and tolerated. Maximum 20 mg daily can be given.

Contraindications:

Tradive dyskinesia and the patients those are hypersensitive to procyclidine.

Precaution:

It should be given with caution in children & geriatric patients. It is advisable to be cautious in giving Extranil to patients with diarrhoea and cardiovascular diseeases, glaucoma, urinary retention, hepatic or renal impairment.

In Pregnancy and Lactation:

No data is advisable on the safe use of this drug in pregnancy and lactation.

Side Effects:

Dryness of mouth, blurring of vision, giddiness, gastro-intestinal disturbances (nausea, vomiting, epigastria, distress, constipation), allergic reaction (e.g. rash) or muscular weakness may occasionally occur. High doses may cause vertigo and possible confusion and hallucination, Side effects may usually be minimized by adjustment of dosage and administration after meal.

Drug Interaction:

Phenothiazines, anticonvulsants, levodopa, ketoconazole, monoamine oxidase inhibitors, adsorbent antidiarrhoeals, alcohol, anticholinergic drugs.

Storage condition:

Keep in a cool and dry place, protected from light.

Commercial pack:

Each box contains 10 blister strips of 10 tablets.