Trade Name: DELETA TABLET
Generic Name:
Flupenthixol+Melitracen
What is Anxiety?
Anxiety is an unpleasant state of tension, apprehension, uneasiness- a fear that
seems to arise from an unknown source.
Symptoms of anxiety :
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a) Palpitation
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b) Tachycardia
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c) Sweating
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d) Tremor
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e) Hypertension
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f) Restlessness
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g) Agitation
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h) GIT disorders
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i) Sleep disturbance.
What is Depression?
Low mood
Loss of pleasure or interest
Loss of energy or increased tiredness
Cause of Depression :
Deficiency of monoamines such as nor-adrenaline and serotonin at certain key
sites of the brain.
Prevalence of Psychiatric disorder : Anxiety & Depression
WHO Study on Psychological problem in General Health Care :
The most common diagnosis of psychiatric disorders were current depressive
episode and Generalized anxiety Disorder ( GAD) in primary care ( ICD-10)
Ref : An international Study.
Chichester, England : Wilet Press; 1995 : 323-334
J Clin Psychiatry 2001; 62 (suppl 13) : 31-36
Over half the cases of depression and anxiety appeared in the same patients at
the same time, making them the most frequently comorbid disorders
From Van- diagram;
Percentage of comorbid disorders in current anxiety disorder patients : (10.5%
-5.6%) = 4.9%
Percentage of comorbid disorders in current depressive disorder patients :
(11.7% - 7.5%) = 4.2%
Average percentage of anxiety comorbid with depression patients : (4.9% + 4.2%)
/ 2 = 4.6% .
Ref : Sartorius N, Ustun TB, Lecrubier Y, et al. Br J psychiatry 1996;30 (suppl)
: 38-43.
J Clin Psychiatry 2001; 62 (suppl 13) : 31-36
What is Deleta?
Deleta is a distinctive combination for anxiety comorbid with depression. Low
dose of Flupenthixol is an anti-depressive drug with anxiolytic properties.
Melitracen is a bipolar thymoleptic with activating properties. This combination
renders an excellent mood stabilizing effect with antidepressant, anxiolytic and
activating properties.
Mode of action of Deleta :
Flupenthixol is a dopamine D1 & dopamine D2 receptors antagonist, which stops
the neurotransmitter binding to its receptor sites and Melitracen is a
nor-adrenalin and serotonin reuptake inhibitor at the synapse in the brain.
What are the indications?
In the treatment of anxiety, depression, and apathy.
Maintenance in Psychogenic depression and other psychoses.
Dosage and administration :
Adult : Usually 2 tablets daily divided in the morning and evening.
In severe case : Morning dose may be increased to 2 tablets.
Elderly Patients : 1 tablet in the morning.
Maintenance Dose : Usually 1 tablet in the morning.
Child : Not recommended.
During pregnancy and lactation :
Should be avoided during pregnancy and lactation.
Deleta Tablet :
Each film-coated tablet contains Flupenthixol INN 0.5 mg and Melitracen INN 10
mg.
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