Trade Name: ARIPRAZOLE TABLET 5 MG
Generic Name:
Ariprazole INN
Presentation:
Ariprazole 5 : Each
film-coated tablet contains Aripiprazole INN 5 mg.
Ariprazole 10 : Each film-coated tablet contains Aripiprazole INN 10 mg.
Indications:
Dosage & Administration:
Schizophrenia: Usual
recommended starting and target dose for aripiprazole is 10 to 15 mg/day
administered on a once-a-day schedule without regared to meals. Aripiprazole has
been shown to be effective in a dose range of 10 to 30 mg/day Maximum dosage
increase should not be made befor 2 weeks.
Acute manic & mixed episodes
associated with bipolar disorder: Usal recommended starting dose is 30 mg
given once a day. Does may be dereased to 15 mg based on assessment of
tolerability.
Dosage adjustment are not
routinely indicated on the basis of age, gender, race or renal or hepatic
impairment status.
Cautions:
Aripiprazole should be used
cautiously in patients at risk of orthostatic hypotension, seizure, patients for
cognitive and motor impairment, dysphagia, suicide, in patients with concomitant
illness, elderly, pregnancy.
Side effects:
Headache, asthenia, fever,
nausea, vomiting, constipation, anxiety, insomnia, lightheadedness, somnolence,
akathisia, tremor, rhinitis, coughing, rash, postural hypotension, dyspepsia and
blurred vision. Neuroleptic malignant syndrome, tardive dyskinesia,
hyperglycemia and diabetes mellitus have been rarely seen during aripiprazole
therapy.
Contraindications:
Aripiprazole is contraindicated
in patients with a known hypersensitivity to the product; child, adolescent &
breast feeding mothers.
Drug interactions:
ketoconazole and quinidine
increase the AUC of aripiprazole; so dose should be reduced by half when
co-administered with these drug. Carbamazepine decreases the AUC of aripiprazole;
so dose should be doubled while carbamazepine is co-administered.
Pregnancy and Lactation:
Aripiprazole should be used in
pregnancy only if the potential benefits outweigh the potential risk to the
fetus and it is recommended that women receiving aripiprazole should not
breast-feed.
Commercial pack:
Ariprazole 5 : Each box
contains 5 blister strips of 10 tablets.
Ariprazole 10 : Each box contains 3 blister strips of 10 tablets.
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