Trade Name: MUCOLEX D/S
Generic Name: Carbocisteine

Presentation :
Mucolex capsule 375 mg 
Mucolex suspension 100 ml. 

Mucolytics : 
Mucolytics are the agents that facilitate expectoration by reducing sputum viscosity. Regular use of oral mucolytics may be of some benefit in patients with chronic obstructive pulmonary disease who suffer from exacerbations. Steam inhalation with postural drainage is good expectorant therapy in bronchiectasis and in some cases of chronic bronchitis. 

Available Mucolytics : 
Carbocisteine, Bromhexine, Methyl Carbocisteine.

Mechanism of Action : 
Carbocisteine is a derivative of acetylcysteine, it is blocked thiol group. Its major action is on the metabolism of mucus producing cells. The mucus produced under the influence of carbocisteine, has an increased sialomucin content. Sialomucins influence the rheological properties of mucus and may also, through inhibition of kinins, reduce or prevent bronchial inflammation and bronchospasm.

Indications :
Carbocisteine is indicated especially for chronic respiratory conditions like bronchitis, bronchial obstruction as in asthma, bronchiectasis, upper respiratory tract congestion, glue ear, otitis media, sinusitis, and rhinopharyngitis.

High lighting features

Superiority than Bromhexine

• Carbocisteine suppressed the development of ciliary lesions of the tracheal and bronchial mucosa, while Bromhexine showed no such effects.

• Carbocisteine provides clinical improvement of cough four days ahead of Bromhexine.

• Carbocisteine inhibited or improved all SO2-induced changes while Bromhexine showed no such effect.

Superiority from other Mucolytic

1. Mucolex dose not cause drowsiness or dependence.
2. There is no precautionary measure for asthma patients.
3. Mucolex dose not cause CNS depression or excitation.