Please read the question and write down the correct answer(s) (i.e a,b,c,d) as applicable against each quiz number in the Medi Quiz answer card on the Business Reply Card. More then one answers may be given i.e a,d .
   
   
  1. Thalassemia is
 
  The most prevalent genetic blood disorder in the world.
  The name thalassemia comes from the Latin root thalassa, meaning "the sea,"
  This is first described by pediatrician Thomas B.Cooley, in 1925
  Thalesemia major is also called Cooley's Anemia
 
  2. Hemoglobin
 
  Molecular weight 64500
  Hemoglobin F consists of 2α2έ
  A total of two alpha globin genes exist in each cell
  In beta thalassemia there is point mutations rather then deletion.
     
  3. Differential Diagnosis of thalassemia consists
 
  Congenital dyserythropoietic anemia
  Iron deficiency anemia.
  Acute leukemia.
  Sickle cell disease
 
  4. In thalassemia theatment
 
  Blood transfusion should be initiated at an early age when the child is asymptomatic.
  Feritin level is always correlate with iron overload status.
  Chelation therapy should be initiated after 1-2 years of transfusions.
  Eye and hearing examinations should be done every 6-12 months in chelation therapy.
 
  5. Spleen in thalassemia
 
  Acts as a store for nontoxic iron.
  Early removal of the spleen may be harmful.
  If the ladile iron pool in the spleen becomes the target for desferroxamine the splenectomy is justified.
 

Splenectomy may be beneficial in patients who require more then 200-250 ml/kg of packed RBC per year.

 
  6. Diet in thalassemia
 
  Drinking coffee or tea helps to decrease absorption of iron in the gut.
  Large doses of vitamin C should be given.
  Folic acid deficiency can be prevented by supplementation (1 mg/d).
  Small doses of vitamin E should be supplemented.
 
  7. In thalassemia:
 
  CBC, PBF examination, and Hb electrophoresis usually are sufficient to reach the diagnosis.
  Thalassemia minor is associated with a markedly elevated RDW.
  Elevated Hb Bart in newborns with alpha thalassemia trait.
  HLA typing is performed for patients for whom bone marrow transplantation is considered.
     
  8. High-fiber diets beneficial in
     
  Colon cancer
  Heart disease
  Parkinson's disease
  Gastroesophageal reflux disease (GERD)
     
  9. Esomeprazole
     
  Proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+ - ATPase in the gastric parietal cell.
  First PPI to gain approval for on-demand treatment to maintain symptom in reflux disease in patients without oesophagitis.
  Contraindicated in known hypersensitivity to any macrolide antibiotic.
  Dose adjustment is necessary in Renal insufficiency.
     
  10. Alton in
     
  Lansoprazole
  Esomeprazole
  Pantoprazole
  PPI